1-(4-Bromophenyl)-1-(4-nitrobenzoyl)thiourea

2-(4-Bromophenyl)-2-methyl­propan­amide

In the crystal of the title compound, C(10)H(12)BrNO, inversion dimers linked by pairs of N-H⋯O hydrogen bonds generate R(2) (2)(8) loops. Further N-H⋯O hydrogen bonds link the dimers into sheets propagating in (100).

Ethyl 2-(4-bromophenyl)-1-[3-(1H-imidazol-1-yl)prop­yl]-1H-benzimidazole-5-carboxyl­ate monohydrate

In the title compound, C(22)H(21)BrN(4)O(2)·H(2)O, the two pyrazole rings are essentially planar [maximum deviations 0.002 (1) and 0.002 (1) Å], and form a dihedral angle of 73.46 (9)°. The dihedral angle between the benzene rings is 29.33 (7)°. In the crystal, mol-ecules are connected via C-H⋯O and O-H⋯N hydrogen bonds, forming layers in the ab plane.

Synthesis of 1-{4-[4-(adamant-1-yl)phenoxymethyl]-2-(4-bromophenyl)- 1,3-dioxolan-2-ylmethyl}imidazole with expected antifungal and antibacterial activity.

A multistep synthesis of a new analogue of ketoconazole, which was expected to show antifungal and antibacterial activity, has been described.

Ethyl 5-(4-Bromophenyl)-4-methyl-1H-pyrrole- 2-carboxylate

This note describes a sequence converting an oxime-substituted pyrrolidine into a trisubstituted pyrrole structure. The synthetic route is based on a double chlorination of the pyrrolidine substrate followed by the base induced formation of both an imine and a nitrile oxide functionality. The latter reacts with an immobilized thiourea to yield an isothiocyanate which upon elimination generates ...

Cover Vol.4, No.1 April 2007